This activity was supported by Contract No. HHSN263201800029I / Order No. 75N98019F00852 from the U.S. National Institutes of Health, Grant No. 2019 HTH 009 from the Rockefeller Foundation, and Grant ...

The genome is the complete set of DNA within a cell, encompassing protein-coding genes, non-coding elements and vast tracts of intergenic sequence. In eukaryotes, this information is packaged into ...

Every cell in the human body carries the same 3 billion letters of DNA, yet a neuron, a heart muscle cell and a pancreatic beta cell each use that shared code to do entirely different jobs. How cells ...

The human genome has to be carefully organized so it will fit inside of the nuclei of cells, while also remaining accessible to the cellular machinery that works to express the right genes at the ...

DNA doesn’t just sit still inside our cells — it folds, loops, and rearranges in ways that shape how genes behave. Researchers have now mapped this hidden architecture in unprecedented detail, showing ...

Structural variants (SVs) are alterations in the DNA sequence that involve large-scale changes, typically longer than 50 base pairs. Advances in long-read sequencing have significantly increased ...

A new study led by Francesca Storici, a professor in the School of Biological Sciences and faculty member of the Parker H.

A research team led by Zhiping Weng, Ph.D., and Jill Moore, Ph.D."18, at UMass Chan Medical School, has nearly tripled the known number of potential regulatory elements in the genome to 2.37 million, ...

Genome stability during DNA replication depends on a coordinated network of enzymatic activities that ensure accurate duplication and mitigate threats arising from DNA lesions, replication impediments ...

The human genome is a rich, complex record of migration, encounters, and inheritance written over thousands of millennia. Genomic research by members of Sarah Tishkoff's lab at the University of ...

Although there are striking differences between the cells that make up your eyes, kidneys, brain and toes, the DNA blueprint for these cells is essentially the same. Where do those differences come ...